Apollomics has dosed the first participant in a Phase III clinical trial of its new drug, APL-106 (uproleselan injection), in China to treat relapsed or refractory acute myeloid leukaemia (AML) patients.

Uproleselan has been licensed by Apollomics in the Greater China region from GlycoMimetics, which discovered and developed the drug.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The drug can potentially hinder E-selectin from adhering to blood cancer cells, to destroy the leukemic cell resistance mechanism within the bone marrow microenvironment.

The randomised, placebo-controlled, double-blind, bridging trial will assess uproleselan efficacy along with chemotherapy versus chemotherapy alone to treat adult patients with relapsed/refractory AML.

Nealy 140 adults with primary refractory or relapsed AML, who are eligible for induction chemotherapy, will be enrolled in the trial.

Overall survival is the primary goal of the trial while remission rate and duration; and uproleselan’s ability to reduce oral mucositis rate will be included as secondary goals.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The company plans to carry out the trial at nearly 20 blood cancer clinical research centres in the country.

This trial is part of Apollomics’ complete development programme in China, which also comprises a Phase I pharmacokinetic and tolerability trial currently underway.

Apollomics co-founder, chairman and CEO Guo-Liang Yu said: “As our first Phase III clinical trial, dosing of the first patient with APL-106 is a major inflection point for Apollomics as we now become a company in late-stage development.

“APL-106 acts via an innovative mechanism that drives cancer cells out of the bone marrow, making them a prime target to be killed by chemotherapy.

“This combined treatment approach could have a meaningful impact on the lives of patients living with relapsed or refractory AML.”

AML is a kind of cancer that affects blood and bone marrow.