A total of 89 subjects who are unvaccinated or have early-stage breakthrough Covid-19 were enrolled in the trial. Credit: fernando zhiminaicela from Pixabay.

SyneuRx International has concluded subject enrolment in the Phase II clinical trial of the new Covid-19 oral antiviral candidate, SNB01 (Pentarlandir). 

Pentarlandir acts on the main protease, or 3CL-protease and hinders TMPRSS2 for entry of the virus.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The double-blind, placebo-controlled trial will assess the safety, efficacy, pharmacokinetics (PK), viral shedding and clinical effects of Pentarlandir UPPTA in individuals with early Covid-19. 

A total of 89 subjects who are unvaccinated or have early-stage breakthrough Covid-19 were enrolled in the trial.

These participants were randomised to receive either high-dose or low-dose of the antiviral or placebo. 

SyneuRx founder and CEO Emil Tsai said: “Covid-19 continues to plague many parts of the world, including individuals who are immunocompromised, unvaccinated or not up to date on vaccines, or who experience breakthrough infection even when vaccinations are up to date. 

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“Our goal from the start has been to introduce a safe, effective and accessible therapeutic with multiple use cases, including the ability to work against most Covid-19 variants and treat certain influenza strains in order to keep high-risk patients from hospitalisation due to the potential ‘twindemic’ caused by Covid-19 and/or influenza.”

Pentarlandir was found to show initial efficacy and an encouraging safety profile against various variants of the SARS-CoV-2 virus, including Omicron and Delta, as well as several influenza viruses, in preclinical studies.

This trial will enable selection of an optimal dose for the Phase III trial study, anticipated to commence soon.

It will assess the broad-spectrum antiviral activity of Pentarlandir in hindering SARS-CoV-2 and influenza viruses, including rigorous safety evaluations.

In November last year, the company reported that the antiviral entered the final segment of the Phase II trial and neared the Phase III trial.