The trial will explore ISM3312’s safety and efficacy in different subgroups of patients with Covid-19. Credit: 21c CMM on Unsplash.

Insilico Medicine has announced plans to commence clinical trials of its orally available 3CLpro inhibitor ISM3312 in China for the treatment of Covid-19 patients.

The latest move comes after the company received approval from the China National Medical Products Administration (NMPA) for the Investigational New Drug (IND) application submitted for ISM3312.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The clinical trial will explore the safety, tolerability, and pharmacokinetic profile of the drug designed by Insilico’s generative chemistry AI platform, Chemistry42.

In addition, the trial will explore ISM3312’s safety and efficacy in different subgroups of patients with Covid-19.

This is expected to provide an alternative option for health management in the post-pandemic period.

The highly selective small molecule inhibitor ISM3312 attaches to the target protein in an irreversible, covalent binding mode.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Its new molecular structure provides wide anti-coronavirus activity, potential drug-resistant mutations, and single agent oral bioavailability.

Insilico Medicine co-CEO and chief scientific officer Feng Ren said: “Insilico fully utilised its unique features in this internal Covid research and development (R&D) programme by leveraging AI capabilities with R&D expertise to design an innovative 3CLpro inhibitor with novel structure and molecular backbone.

“ISM3312 has significant differences and distinct advantages from existing 3CL protease inhibitors. We are committed to accelerating clinical trials through fast-tracking development policy of the treatment for Covid-19 to benefit patients worldwide.”

ISM3312 significantly minimised viral load in lung tissue and decreased inflammation in lungs in preclinical trials.

Insilico Medicine founder and CEO Alex Zhavoronkov said: “We’re extremely happy to announce that our second small molecule therapeutic generated using generative AI is now entering human clinical trials and there is a very clear timeline to demonstrate the discovery and development cycle.”