Transfusion independence rate for red blood cells and/or platelets in the trial was 29%. Credit: allinonemovie from Pixabay.

Karyopharm Therapeutics has reported interim data from the Phase II portion of its open-label Phase I/II trial of single-agent eltanexor (KPT-8602) for the treatment of higher relapsed/refractory myelodysplastic neoplasms.

The study treated 30 patients with 10mg eltanexor orally on days 1-5 of each week, until February of this year.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Eltanexor was found to be well-tolerated with manageable safety profile and has promising single-agent efficacy.

It also demonstrated a 31% overall response rate in the efficacy evaluable population and a 27% ORR in the intent-to-treat population.

In the trial, transfusion independence rate for red blood cells and/or platelets was 29% while median overall survival was 8.7 months in both populations.

Karyopharm chief medical officer Reshma Rangwala said: “Existing first-line treatments for higher risk MDS are not typically curative; approximately half of these patients do not respond. Upon progression, median overall survival for these higher risk, relapsed or refractory MDS patients is approximately four to six months.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“We are encouraged by the improved overall survival observed to date with eltanexor in this higher risk patient population.

“These preliminary results are promising and reinforce the potential of XPO1 inhibition to provide meaningful clinical benefit to patients with relapsed/refractory myelodysplastic neoplasms.”

Eltanexor is an investigational SINE compound which inhibits XPO1, a nuclear export protein leading to the accumulation of tumour suppressor proteins in the cell nucleus.