Ecnoglutide’s safety and tolerability profile in the trial was in line with that of GLP-1 receptor agonists. Credit: H_Ko / Shutterstock.com.

Sciwind Biosciences has reported positive topline results from a Phase III clinical trial of ecnoglutide (XW003), a long-acting, cyclic adenosine 3′,5′-monophosphate (cAMP) signalling biased glucagon-like peptide-1 (GLP-1) analogue, in adult type 2 diabetes mellitus (T2DM) patients in China.

The double-blind, randomised, placebo-controlled trial enrolled 211 subjects across 33 sites in the country.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Subjects with inadequately controlled T2DM were randomised to receive weekly injections of ecnoglutide or a placebo for 24 weeks, including a dose escalation period.

Variations in mean haemoglobin A1c (HbA1c), body mass index (BMI), body weight, tolerability, and safety were assessed int the trial.

After 24 weeks, subjects who were given ecnoglutide attained a statistically significant decline in HbA1c.

Most of the subjects in the ecnoglutide arm attained HbA1c levels below 7%, and a substantial portion also had HbA1c levels below 5.7%.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Significant weight loss was also observed in participants receiving ecnoglutide.

Ecnoglutide’s safety and tolerability profile in the trial was in line with that of GLP-1 receptor agonists.

Sciwind Biosciences CEO Hai Pan said: “We are very pleased to see the positive results from the first Phase III clinical trial of ecnoglutide in China.

“The HbA1c reductions observed after 24 weeks of treatment are very promising, and are comparable to the treatment effects seen with dual GLP-1/GIP analogues, such as tirzepatide.

“The strong efficacy we are seeing with ecnoglutide in clinical studies is consistent with its cAMP signalling biased mechanism of action.”

Apart from this Phase III trial in T2DM patients, ecnoglutide is also being analysed in two other Phase III studies.

These studies are fully enrolled and are assessing ecnoglutide versus dulaglutide in T2DM, and ecnoglutide versus a placebo in people who are overweight or obese.

Trial data from both studies are anticipated in the second half of next year.

In October 2022, the company began dosing subjects in a Phase I trial of XW014 in development to treat obesity and type 2 diabetes.