US-based biopharmaceutical company Nurix Therapeutics has reported positive clinical data from its ongoing Phase Ia/Ib trial of NX-5948, a BTK degrader designed to treat relapsed/refractory Waldenstrom’s macroglobulinaemia (WM).
The findings were shared at the 12th International Workshop on Waldenstrom’s Macroglobulinemia in Prague, Czech Republic, which was held from 17 to 19 October.
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WM is a rare non-Hodgkin’s lymphoma marked by abnormal lymphocytes and monoclonal immunoglobulin M (IgM) production.
As of 17 April, the trial data showed NX-5948’s safety across all dosages from 50mg to 600mg administered orally daily.
In the trial, the therapy showed an objective response in seven out of nine evaluable patients (77.8%), with two patients showing stable disease.
Seven responses were recorded at the first eight-week assessment while five patients are still undergoing treatment, with two of these patients having been treated for more than a year.
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By GlobalDataNurix chief medical officer Paula O’Connor said: “We are encouraged by the emerging positive data from NX-5948 in patients with Waldenstrom’s macroglobulinemia, which adds to the previously disclosed robust clinical activity observed in patients with chronic lymphocytic leukaemia.
“These data support our decision to advance NX-5948 into the ongoing Phase 1b expansion cohort in patients who have previously received at least one prior line of therapy including a BTK inhibitor and patients presenting with Bing-Neel syndrome, a rare form of WM with central nervous system involvement where NX-5948’s ability to penetrate the brain may offer a distinct advantage.”
Further data from 10 October included details on the first 13 WM subjects enrolled in both the Phase Ia and Ib stages of the trial.
These patients had a median age of 74 and had undergone an average of three previous therapies, including BTK inhibitors and chemo-immunotherapy.
Based in California, Nurix Therapeutics focuses on developing and commercialising therapies for cancer, inflammatory conditions and other diseases.
