The trial is set to take place across investigator sites in Europe, the US and the Asia-Pacific region. Credit: Amnaj Khetsamtip / Shutterstock.

Canadian biotechnology company Zymeworks has dosed the first subject in a Phase I trial of ZW171 to treat advanced or metastatic ovarian cancer, non-small cell lung cancer (NSCLC) and other mesothelin-expressing cancers.

ZW171 is engineered to kill T cell-mediated tumour cells by concurrently targeting the extracellular domain of the mesothelin protein on tumour cells and the cluster of differentiation 3 on T cells.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The first-in-human Phase I study is a two-part, multi-centre, open-label trial that is anticipated to enrol around 160 adult subjects with advanced mesothelin-expressing cancers.

The first part of the trial will focus on assessing ZW171’s tolerability and safety, involving dose escalation in advanced ovarian and NSCLC patients.

Secondary endpoints will evaluate pharmacokinetics alongside the confirmed objective response rate.

See Also:

The study’s second part will assess ZW171’s anti-tumour activity across ovarian cancer and NSCLC cohorts, as well as a basket cohort for subjects with any mesothelin expression.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

This stage’s primary endpoints will examine tolerability and safety, while its secondary endpoints will evaluate the duration of response rates, progression-free survival and overall survival.

The trial is set to take place across investigator sites in Europe, the US and the Asia-Pacific region.

Zymeworks executive vice-president and chief medical officer Jeff Smith said: “We are very pleased to have initiated the clinical evaluation of ZW171 for the treatment of patients with ovarian cancer and NSCLC, where it has the potential to be a highly effective therapy with favourable tolerability based on our preclinical research results.

“Initiation of this trial marks a significant step forward in our effort to bring a potential new treatment to people living with difficult-to-treat cancers and highlights our goal to advance two therapeutic candidates, ZW171 and ZW191, into clinical studies in 2024.

“Our trial is designed to rapidly generate clinical data on our differentiated product profile relative to other mesothelin-expressing therapeutics in clinical development.”