Novartis has reported that Phase II data for the new inhaled combination treatment IND/GLY/MF (QVM149) demonstrated significant improvements over existing standard-of-care inhaled treatment.

The new data for QVM149, an investigational, once-daily, fixed-dose combination asthma treatment containing indacaterol acetate, glycopyrronium bromide, and mometasone furoate, was delivered with the Breezhaler inhalation device.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Novartis noted that QVM149 was superior to the comparators, salmeterol / fluticasone propionate and placebo, in two Phase II clinical trials. Separately, an improvement was seen in lung function in patients with asthma.

In one study, the treatment also demonstrated improvements versus placebo irrespective of administration time of morning or evening.

In the Phase II CQVM149B2208 study, both once-daily doses met the primary endpoint with significant improvements of peak forced expiratory volume in 1 second (FEV1) versus twice daily salmeterol / fluticasone propionate with mean differences of 172ml and 159ml.

Compared with salmeterol / fluticasone propionate 50/500 mu g twice a day, both high and medium doses of QVM149 also met the secondary endpoint with statistically significant improvements.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Novartis Respiratory Development Unit head Linda Armstrong said: “Despite the availability of numerous asthma treatments, more than one-third of asthma patients remain uncontrolled and continue to experience symptoms and / or exacerbations.

“Together with a dose-confirming Breezhaler inhalation device, which is well established in COPD, this new combination, if approved, has the potential to improve the lives of those with uncontrolled asthma.”

“This new combination, if approved, has the potential to improve the lives of those with uncontrolled asthma.”

In the CQVM149B2209 study, the treatment provided consistent and substantial lung function benefits for 24 hours over the entire dosing interval in adult patients with asthma.

The study demonstrated the improved FEV1 for the morning and evening administrations of QVM149 compared to placebo over 14 days and met the primary endpoint.

Based on the safety data from both studies, it has been found that the treatment has a favourable safety and tolerability profile.