CAR-Ts have been hailed as game-changers for patients with relapsed/refractory blood cancers that are resistant to standard treatments.
2017 saw the approval of two CAR-T therapies: Novartis’ Kymriah and KITE/Gilead’s Yescarta. However, lack of access and continued safety concerns are two factors limiting the commercial potential of approved CAR-T treatments.
Go deeper with GlobalData
Commercial barriers: Two months after KITE/Gilead’s Yescarta gained FDA approval, only five patients had been treated with the drug outside of clinical trials.
Delays in access have been blamed on lack of insurance coverage, particularly with Medicare and Medicaid, due to absence of reimbursement infrastructure as well as payer pushback at the high cost of these treatments (Kymriah costs $475,000 per patient while Yescarta costs $373,000 per patient).
Adding to the discussion on whether the cost of these drugs are justified, there is lack of mature clinical data showing these treatments to be curative. Cytokine release syndrome continues to be a safety concern when administering CAR-T treatments.
How well do you really know your competitors?
Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Thank you!
Your download email will arrive shortly
Not ready to buy yet? Download a free sample
We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form
By GlobalDataLooking ahead: Despite lingering safety and pricing concerns, developers are forging ahead with the next generation of CAR-T drugs using novel targeting approaches (bispecific CAR-T) and production strategies (“off-the-shelf” CAR-T).
Related Company Profiles
Medicare Corp.