Global clinical trials activity decreased by 8.8% in Q4 2022, when compared with the same quarter in 2021, according to GlobalData.
Industry sponsored trials accounted for a 54.4% share of overall activity in Q4 2022, a decrease of 0.7% when compared with Q4 2021.
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Non-industry sponsored trials accounted for a 45.6% share of all clinical trials in Q4 2022, marking an increase of 0.7% when compared with the same period in 2021.
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Q4 2022 industry sponsored clinical trials activity by therapy areas
Oncology was the leading therapy area for industry sponsored clinical trials in Q4 2022, accounting for a 30.2% share of all trials.
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By GlobalDataThis was followed by Central Nervous System with a 15.9% share, Infectious Disease with 12.7%, Metabolic Disorders with 7.3% and Gastrointestinal with 6.5%.
In Q4 2021, Oncology led with a 27.6% share, followed by Infectious Disease with 16.2%, Central Nervous System with 14.3%, Cardiovascular with 8.2%, and Gastrointestinal with 7.6%.
| Industry sponsored trials: Q4 2022 vs Q4 2021 | |||
|---|---|---|---|
| Therapy Area | Q4 2021 | Q4 2022 | Activity |
| Oncology | 27.6% | 30.2% |  |
| Central Nervous System | 14.3% | 15.9% | |
| Infectious Disease | 16.2% | 12.7% |  |
| Metabolic Disorders | 7.1% | 7.3% | |
| Gastrointestinal | 7.6% | 6.5% | |
| Cardiovascular | 8.2% | 6.4% | |
| Immunology | 6.0% | 5.5% | |
| Respiratory | 6.3% | 4.7% | |
| Dermatology | 5.0% | 4.3% | |
| Musculoskeletal Disorders | 4.0% | 3.3% | |
| Ophthalmology | 3.1% | 3.3% | |
| Hematological Disorders | 2.8% | 2.9% | |
| Genito Urinary System And Sex Hormones | 2.3% | 2.6% | |
| Genetic Disorders | 2.1% | 2.2% | |
| Women’s Health | 2.0% | 1.7% | |
| Male Health | 0.9% | 0.8% | |
| Ear Nose Throat Disorders | 1.9% | 0.6% | |
| Hormonal Disorders | 0.9% | 0.6% | |
| Mouth and Dental Disorders | 0.6% | 0.5% | |
| Non Malignant Disorders | 0.2% | 0.2% | |
| Nutritional Disorders | 0.2% | 0.2% | |
Most active therapy areas in non-industry sponsored clinical trials
In Q4 2022 the leading therapy area for non-industry sponsored clinical trials was Central Nervous System, accounting for a 27.7% share of all trials.
This was followed Oncology with a 24.2% share, Cardiovascular with 10.0%, Infectious Disease with 8.6%, and Gastrointestinal with 6.5%.
In Q4 2021, Central Nervous System held the lead in non-industry sponsored clinical trials with a 24.9% share, followed by Oncology with 23.5%, Infectious Disease with 13.6%, Cardiovascular with 8.9%, and Gastrointestinal with 6.1%.
| Non-Industry sponsored trials: Q4 2022 vs Q4 2021 | |||
|---|---|---|---|
| Therapy Area | Q4 2021 | Q4 2022 | Activity |
| Central Nervous System | 24.9% | 27.7% | |
| Oncology | 23.5% | 24.2% | |
| Cardiovascular | 8.9% | 10.0% | |
| Infectious Disease | 13.6% | 8.6% | |
| Gastrointestinal | 6.1% | 6.5% | |
| Metabolic Disorders | 5.1% | 5.5% | |
| Musculoskeletal Disorders | 4.4% | 5.3% | |
| Women’s Health | 5.0% | 4.9% | |
| Respiratory | 4.3% | 3.8% | |
| Genito Urinary System And Sex Hormones | 2.7% | 3.5% | |
| Dermatology | 2.9% | 3.4% | |
| Hematological Disorders | 2.8% | 3.3% | |
| Immunology | 2.9% | 3.2% | |
| Mouth and Dental Disorders | 2.3% | 2.5% | |
| Ophthalmology | 2.1% | 1.6% | |
| Ear Nose Throat Disorders | 1.2% | 1.2% | |
| Genetic Disorders | 0.6% | 1.1% | |
| Nutritional Disorders | 0.7% | 1.0% | |
| Hormonal Disorders | 0.8% | 0.8% | |
| Male Health | 0.7% | 0.5% | |
| Non Malignant Disorders | 0.3% | 0.3% | |
Asia-Pacific region has the most activity for industry sponsored clinical trials
Asia-Pacific was the most active region for industry sponsored clinical trials activity in Q4 2022 with a 50.3% share, compared with 57.0% in Q4 2021.
North America was the second most active region with a 36.8% share in Q4 2022, up from 29.2% in Q4 2021, followed by Europe with a 27.6% share in Q4 2022, remaining flat when compared with 27.6% in Q4 2021.
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Single country studies held an 83.8% share in industry sponsored clinical trials in Q4 2022, compared with 84.4% in Q4 2021. Multinational trials accounted for 16.2% in Q4 2022, against 15.6% in Q4 2021.
Regional activity for non-industry sponsored clinical trials
Asia-Pacific saw the most non-industry sponsored clinical trial activity in Q4 2022 with a 57.2% share, up from 49.6% in Q4 2021.
North America held the second position with a 19.3% share in Q4 2022, compared with 15.6% in Q4 2021. This was followed by Middle East and Africa with a 12.3% share in Q4 2022, as against 19.9% in Q4 2021.
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Single country studies accounted for 98.9% share of non-industry sponsored clinical trials in Q4 2022, compared with 98.6% in Q4 2021. Multinational trials accounted for a 1.1% share in Q4 2022, down from 1.4% in Q4 2021.
Clinical trials by phase in Q4 2022
Phase II trials outnumbered all other studies with a 37.9% share for industry sponsored trials in Q4 2022, compared with 33.7% in Q4 2021.
The share of Phase I trials stood at 35.0% in Q4 2022, down from 40.4% in Q4 2021. Phase III trials increased to 18.7% in Q4 2022, compared with 15.3% in Q4 2021, followed by Phase IV trials with an 8.4% share in Q4 2022, against 10.6% in Q4 2021.
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For non-industry sponsored clinical trials, Phase II activity increased to a 49.0% share in Q4 2022, compared with 39.6% in Q4 2021.
Phase IV trials were the second most active with a 20.4% share in Q4 2022, compared with 22.6% in Q4 2021. Phase III trials held a 15.5% share in Q4 2022, against 20.4% in Q4 2021, followed by Phase I trials with a 15.1% share in Q4 2022, over 17.4% in Q4 2021.
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Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.
