Amgen’s Krystexxa is currently approved by the Food and Drug Administration to treat uncontrolled gout in adults. Credit: JHVEPhoto / Shutterstock.com.

Amgen has reported findings from the MIRROR clinical trial where its Krystexxa (pegloticase) therapy reduced blood pressure in chronic gout patients. 

The controlled, randomised trial enrolled 152 adult subjects with chronic gout refractory to oral urate-lowering therapy, irrespective of chronic kidney disease (CKD) status.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

They were randomised into a 2:1 ratio to receive Krystexxa plus methotrexate, an immunomodulator or Krystexxa plus placebo for 52 weeks. 

Subjects who received Krystexxa plus methotrexate experienced an increased reduction in systolic blood pressure at week 24 with effects sustaining for more than 52 weeks versus Krystexxa plus placebo. 

Subjects without pre-treatment CKD had a drastic drop in blood pressure after week 24 with variations lasting through week 52 versus those with pre-treatment CKD.

Amgen nephrology medical director Brad Marder said: “As we seek to address the overall burden of uncontrolled gout, especially in those with coexisting chronic kidney disease, it is critical to further understand the benefits of treatment. 

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“Recognising the high prevalence of hypertension among these patients, we’re excited to present data that offers new insight into the potential role of urate reduction with Krystexxa with methotrexate in regulating blood pressure.”

Krystexxa is approved by the Food and Drug Administration to treat uncontrolled gout in adults.

Subsequently, the FDA granted approval for the expanded indication of Krystexxa to be used along with methotrexate.

In September this year, the company reported findings from a Phase Ib part of the CodeBreaK 101 trial of LUMAKRAS (sotorasib) plus carboplatin and pemetrexed to treat KRAS G12C-mutated advanced non-small cell lung cancer.