The thrombolytic agent was well tolerated and safe throughout the study period of 28 days. Credit: ANIRUDH on Unsplash.

Basking Biosciences has announced positive data from a Phase I single ascending dose safety trial of its thrombolytic agent, BB-031, in healthy volunteers.

The company’s new von Willebrand Factor (vWF)-targeting thrombolytic agent BB-031 demonstrated tolerability and safety after a single intravenous dose, and dose-dependent vWF binding patterns and changes in function of platelets.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Healthy volunteers in the Phase I trial were given BB-031 or a placebo in a 6:2 ratio by intravenous bolus at single ascending doses ranging from 0.1mg/kg to 4mg/kg.

It was found that the agent was well tolerated and safe throughout the study period of 28 days, and no significant or treatment-emergent adverse events were reported.

Additionally, BB-031 demonstrated an apparent mean terminal half-life ranging from 18 minutes at 0.1 mg/kg to 61 minutes at 4mg/kg.

Dose-dependent changes in vWF binding were also reported in the study.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

BB-031 is being developed by Basking as a potential solution to the major unmet need in acute thrombosis for a short-acting, rapid-onset drug that can reopen blocked arteries quickly.

Its thrombolytic activity has been designed to be neutralised rapidly during bleeding with the help of a complementary agent, BB-025, which is being developed in tandem.

Basking Biosciences CEO Richard Shea said: “The results of this successful placebo-controlled safety study of BB-031 in 40 healthy participants lay a strong foundation for planned further clinical trials in patients experiencing acute thrombotic conditions.

“We are now preparing to initiate a Phase II clinical proof-of-concept study in patients suffering an acute ischemic stroke with the ultimate goal of being able to safely and effectively treat a much greater number of stroke patients than is possible today.”