New trial evaluates AstraZeneca’s drug candidate for head and neck cancer. Credit: Cancer Research UK.

Cancer Research UK has started a Phase I clinical trial of AstraZeneca’s investigational compound, AZD1775, to improve head and neck cancer treatment.

AZD1775 is a part of the firm’s DNA Damage Response compounds portfolio and is being developed as a potent inhibitor of the WEE1 protein that regulates cell cycles.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The trial is being conducted through Combinations Alliance, a joint initiative by Cancer Research UK and the Experimental Cancer Medicine Centres (ECMC) Network.

It will assess the safety and effectiveness of AZD1775 to minimise the risk of cancer recurrence when combined with cisplatin chemotherapy before surgery, and with cisplatin chemotherapy and radiotherapy after surgery.

In addition, the Phase I trial aims to determine if the pre-surgery combination would reduce the need for further therapy following surgery.

“We hope that combining this drug with chemotherapy will mean that treatment is more effective helping more people survive, and that those cured will have a better quality of life after treatment.”

At the University of Birmingham, one group of up to 21 subjects will be administered with pre-surgery combination, while another group will receive the post-surgery combination.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The trial is designed to enrol patients aged 18-70 who are suffering from mouth, throat and voice box cancer and are yet to undergo surgery.

Trial chief investigator and University of Birmingham Institute of Cancer and Genomic Studies professor Hisham Mehanna said: “Many patients diagnosed with aggressive types of head and neck cancer are at a high risk of relapse after surgery, so we urgently need to find new ways to treat the disease and reduce the risk of it returning.

“We hope that combining this drug with chemotherapy will mean that treatment is more effective helping more people survive, and that those cured will have a better quality of life after treatment.”