Coordination Pharmaceuticals (CPI) has dosed the first patient in a Phase I study of nanoscale coordination polymer (NCP) CPI-200 in patients with advanced tumours.

CPI-200 contains two new molecular entities (NMEs) with synergistic anti-tumour activities.

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The prospective, open-label, single-arm, non-randomised study will evaluate CPI-200 in patients with advanced tumours.

The trial’s primary objectives include determining maximum tolerated dose (MTD), pharmacokinetics (PK), and preliminary anti-tumour activity of CPI-200.

Secondary objectives of the trial are evaluating the PK of CPI-200, clinical response, and resolution of symptoms after CPI-200 treatment.

RiMO founder and chairman Wenbin Lin said: “Initiation of this study represents a significant milestone for CPI as CPI-200 is the company’s third candidate to enter clinical studies in the past year.

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“We believe our two innovative technology platforms have the potential to change treatment paradigms for multiple cancer types and significantly benefit patients.”

CPI is also conducting a Phase I study of CPI-100 and a prospective, open-label, single-arm, non-randomised study of RiMO-301 in patients with advanced tumours.

CPI-100 will be evaluated in patients with advanced tumours as part of the prospective, open-label, single-arm, non-randomised study. It is administered through intravenous infusion in a 3+3 study design to identify the maximum tolerated dose (MTD).

CPI-100 also comprises two synergistic NMEs to activate tumour microenvironments for combination therapy with an immune checkpoint inhibitor.

RiMO-301 elicits unprecedented radiotherapy-radiodynamic therapy (RT-RDT) to improve the efficacy of X-ray radiotherapy.

A single escalation dose of RiMO-301 is intratumorally injected in a 3+3 study design to identify the recommended dose and dosing volumes.