The study participants achieved average weight reductions of 13.4%. Credit: Diana Polekhina on Unsplash.

Eli Lilly and Company has reported that its weight loss therapy, tirzepatide, met both co-primary objectives and all major secondary objectives in the Phase III SURMOUNT-2 trial.

The trial examined the efficacy and safety of tirzepatide for chronic weight management.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

It assessed 938 adults with obesity or overweight and type 2 diabetes.

According to the company, the trial participants who received tirzepatide 15mg lost up to 15.7% of body weight for the efficacy estimand.

They also achieved average weight reductions of 13.4% when treated with tirzepatide 10mg as against a placebo.

Furthermore, 81.6% and 86.4% of the subjects who received tirzepatide achieved a minimum of 5% body weight loss, the other co-primary endpoint of the trial, in comparison with 30.5% of those taking a placebo.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The trial’s secondary objectives included decrease in A1C and other cardiometabolic parameters.

Tirzepatide’s overall safety profile was found to be similar to previously announced SURMOUNT and SURPASS trials and to incretin-based therapies approved for obesity and overweight treatment.

The most common adverse events were gastrointestinal related and generally mild to moderate in severity, which typically happened during the dose-escalation period.

The trial’s overall treatment discontinuation rates were 9.3%, 13.8% and 14.9% for 10mg, 15mg and placebo, respectively.

Eli Lilly and Company product development senior vice-president Jeff Emmick said: “Obesity is a difficult-to-manage disease, and it’s even more difficult for people living with type 2 diabetes.

“The degree of mean weight reduction seen in SURMOUNT-2 has not been previously achieved in Phase III trials for obesity or overweight and type 2 diabetes.”