Ocrevus is the first and only therapy approved for both relapsing forms of MS. Credit: JUAN GAERTNER/SCIENCE PHOTO LIBRARY via Getty Images.

Genentech, owned by Roche, has announced new clinical and real-world data for Ocrevus (ocrelizumab) for the treatment of patients with relapsing multiple sclerosis (RMS) or primary progressive multiple sclerosis (PPMS). 

The results show that after 10 years of continuous Ocrevus treatment, 77% of patients with RMS had no disability progression and 92% of them continued to walk unassisted. In PPMS patients, 36% had no disability progression based on 48-week confirmed disability progression (CDP) events and 80% of those patients were still able to walk unassisted. 

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

The data has been collected from Phase III Ocrevus open-label extension (OLE) trials. The long-term data has emphasised the importance of early treatment, as patients who were treated earlier in their diagnosis reported better treatment outcomes.  

A 10-year safety profile has been curated based on data from 6,155 patients with a combined 28,269 patient-years of exposure to Ocrevus across 12 clinical trials, supporting the long-term safety of the drug.  

Safety data from 3,253 cumulative pregnancies in women with MS who received treatment with Ocrevus do not suggest an increased risk of adverse pregnancy or infant outcomes. 

Director of the Weill Institute for Neurosciences at the University of California Stephen Hauser said: “Ocrevus is the first B-cell therapy approved for RMS and PPMS and it’s remarkable to see that after 10 years of treatment, a great majority of RMS patients remain free from disease progression.”  

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Ocrevus was approved for use in MS in 2017, and was Roche’s top-selling pharmaceutical in 2022, according to the annual 2022 report, making $6.7bn. According to GlobalData, Ocrevus sales are expected to rise to $7.4bn by 2029. GlobalData is the parent company of Clinical Trials Arena. 

In July of this year, Roche announced that the Phase III OCARINA II trial investigating the efficacy of subcutaneous Ocrevus met all of its primary and secondary endpoints. The approval of subcutaneous Ocrevus would introduce flexibility to MS patients who spend time receiving intravenous Ocrevus.