Immune-Onc Therapeutics has announced the dosing of the first subject in its Phase I clinical trial designed to evaluate IO-202 for treating advanced solid tumour patients.
The first-in-class myeloid checkpoint inhibitor IO-202 acts on Leukocyte Immunoglobulin-Like Receptor B4 (LILRB4, which is also known as ILT3).
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The clinical trial comprises dose escalation and dose expansion portions.
During the dose escalation, the tolerability, safety, pharmacokinetics, and pharmacodynamics of IO-202 will be evaluated alone and in combination with anti-PD-1 pembrolizumab.
The dose expansion part will use the recommended dose of IO-202 for the Phase II trial in combination with pembrolizumab in multiple types of solid tumours.
Furthermore, the trial will explore various biomarkers for a mechanistic understanding of clinical data and inform future trials.
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By GlobalDataThe trial is expected to provide an opportunity for identifying IO-202’s preliminary efficacy signals as a single agent and as a combination with a PD-1 inhibitor in advanced solid tumour patients.
Immune-Onc Therapeutics chief medical officer Paul Woodard said: “We are very pleased to announce the initiation of our Phase I study of IO-202 in solid tumours, a significant achievement in our development strategy targeting the LILRB family of myeloid checkpoints to overcome immune suppression in the tumour microenvironment.
“We believe by targeting the LILRB4 checkpoint, IO-202 may reverse the immunosuppressive effects of tumour-associated monocytic myeloid cells, enhance dendritic cell function, and promote T cell activation – thereby, unleashing the antitumour activities of the immune system and increasing the therapeutic benefit of T cell checkpoint inhibitors.”
IO-202 has broad potential as an immunotherapy in blood cancers as well as solid tumours and is currently being evaluated in two clinical studies.
This January, Immune-Onc obtained the US Food and Drug Administration approval for its Investigational New Drug application to start the trial of IO-202.
