According to GlobalData, the ovarian cancer market is forecast to generate $4.1bn in the seven major markets in 2032. Credit: MMD Creative via Shutterstock.

Imunon’s shares soared by 180% yesterday (30 July) following positive data from the Phase II trial of interleukin (IL)-12 immunotherapy plus chemotherapy in ovarian cancer patients.

The OVATION-2 study randomised 112 patients with advanced ovarian cancer to receive the IL-12 immunotherapy called IMNN-001, plus chemotherapy or standard-of-care chemotherapy alone. The combination led to an 11.1-month benefit in median overall survival (OS) in the intent-to-treat cohort. The study was not powered for statistical significance.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

On the trial’s primary endpoint of progression-free survival (PFS), IMNN-001 plus chemotherapy resulted in a three-month improvement versus chemotherapy alone. According to New Jersey-based Imunon, the company now plans to hold an end-of-Phase II meeting with the US Food and Drug Administration (FDA) to discuss the protocol for a Phase III study, which is anticipated to begin in Q1 2025.

IMNN-001 comprises an IL-12 DNA plasmid vector encapsulated in a nanoparticle vehicle. IL-12 is a cytokine that plays a crucial role in the immune response, particularly in enhancing the activities of natural killer cells and T lymphocytes, which are important for attacking cancer cells.  

The IL-12-based therapy has demonstrated efficacy in studies as a cancer immunotherapy. However, its clinical use has been plagued by significant immune-related side effects. According to Imunon’s chief medical officer Sebastien Hazard, the safety profile of IMNN-001 is tolerable. 

Imunon is not the only player exploring IL-12 therapeutics. In March 2024, US pharma giant Gilead Sciences teamed up with Xilio Therapeutics to advance the latter’s IL-12 candidate XTX301 through clinical development. The deal included $43.5m in upfront payments and up to $604m from Gilead Sciences in additional payments. XTX301 is currently being evaluated in an ongoing Phase I clinical trial (NCT05684965).  

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

In the announcement accompanying the data release, Imunon’s CEO Stacy Lindborg said: “These strong and clinically meaningful Phase II results are highly encouraging, suggesting that IMNN-001 may improve the outcomes for women with advanced ovarian cancer. In the near term, we look forward to advancing our therapeutic into a Phase III pivotal study as soon as possible.”  

GlobalData estimates that the ovarian cancer market in the seven major pharmaceutical markets (7MM) (US, France, Germany, Italy, Spain, UK, and Japan) in 2022 was $3.3bn in 2023. By 2032, GlobalData forecasts ovarian cancer drug sales to reach $4.1bn for the 7MM at a compound annual growth rate (CAGR) of 2%. 

GlobalData is the parent company of Clinical Trials Arena.