AA is a chronic autoimmune condition that causes hair loss without scarring. Credit: Alex Papp/ Shutterstock.com.

Inmagene Biopharmaceuticals has dosed the first subject in a Phase IIa trial of IMG-007, an anti-OX40 monoclonal antibody (mAb) with an extended half-life, to treat alopecia areata (AA).

The global multicentre trial will assess the efficacy, safety, biomarkers, and pharmacokinetics of IMG-007 in AA patients with 50% or greater scalp hair loss.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

The humanised IgG1 mAb particularly attaches to the OX40 receptor as well as designed to potently block the signalling between OX40 and its ligand.

IMG-007’s extended half-life enables less frequent dosing while its silenced antibody-dependent cell-mediated cytotoxicity (ADCC) function cuts safety risks.

It has shown a favourable safety profile, without any pyrexia or chill reports, in a Phase I study in healthy adult participants.

See Also:

A single IMG-007 treatment at projected therapeutic dose levels maintained the desired exposure for a duration of 12 to 18 weeks, potentially enabling IMG-007 to be administered every 12 weeks.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

It is also being assessed in a global Phase IIa study in adults with atopic dermatitis (AD) with an interim data readout anticipated in the second quarter of next year.

Inmagene CEO Jonathan Wang said: “Alopecia areata is a devastating disease which affects approximately 147 million people globally. Currently, there are limited treatment options and no approved biologics for AA.

“IMG-007 could potentially provide a safe and effective biologic therapy with once every 12 weeks dosing regimen for AA patients.”

AA is a chronic autoimmune condition causing hair loss without scarring, which can affect the scalp, face, and body.