Gilead Sciences company Kite published Phase II data for Yescarta (axicabtagene ciloleucel) for treating relapsed/refractory (R/R) large B-cell lymphoma (LBCL) in Nature Medicine.
Yescarta is CD-19-directed autologous chimeric antigen receptor (CAR)-T cell therapy. It was first approved by the US Food and Drug Administration (FDA) for large B-cell lymphoma, primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma, and diffuse large B-cell lymphoma (DLBCL) arising from follicular lymphoma.
Go deeper with GlobalData
Yescarta is a high-grossing drug, generating $739m in global sales during H1 2023, as per Gilead’s Q2 financial report. GlobalData forecasts the Yescarta sales to increase to $2.4bn in 2029.
Global Data is the parent company of Clinical Trials Arena.
The open-label Phase II trial (NCT04531046) evaluated Yescarta as a second-line therapy in patients with one prior line of therapy ineligible for high-dose chemotherapy and autologous stem cell transplantation.
The study met its primary endpoint with a complete response rate of 71% and 59.7% in the treatment arm at three and six months, respectively. Negative findings on PET study during or after therapy were considered a complete response.
How well do you really know your competitors?
Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Thank you!
Your download email will arrive shortly
Not ready to buy yet? Download a free sample
We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form
By GlobalDataAt 12-month follow-up, median progression-free survival was 11.8 months, median overall survival was not reached, and overall survival was 78.3%.
The commonly observed serious adverse events were Grade 3-4 cytokine-release syndrome (CRS) or Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS).
In January, The UK National Institute for Health and Care Excellence (NICE) recommended Yescarta for treating relapsed or refractory DLBCL and primary mediastinal large B-cell lymphoma (PMBCL) in adult patients who have previously received two or more lines of systemic therapy.
Cell & Gene Therapy coverage on Clinical Trial Arena is supported by Cytiva. Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.
