Myeloid Therapeutics has announced the dosing of the first patient in the Phase I/II IMAGINE Study of its mRNA engineered CAR monocyte (CAR-M), MT-101, to treat refractory or relapsed peripheral T cell lymphoma (PTCL) patients.

Derived from the company’s ATAK platform, MT-101 targets surface receptor CD5, which is observed in many T cell malignancies.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

The open-label, multicentre, dose-escalation and dose cohort expansion Phase I/II trial will assess MT-101 in patients with refractory or relapsed PTCL, an aggressive form of non-Hodgkin lymphoma.

At present, the Phase I study’s dose-escalation portion, with and without conditioning therapy, is enrolling patients. 

A Phase II trial will begin to support registration in this patient population, once Myeloid establishes the recommended dose for this phase.

On day 28, the primary endpoint for tolerability and safety, no cytokine release syndrome (CRS), no dose-limiting toxicities, and no immune effector cell-associated neurotoxicity syndrome (ICANS) were observed in the patient.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Myeloid Therapeutics chief medical officer Michele Gerber said: “We are pleased to announce the initiation of dosing in the IMAGINE clinical trial, which represents a major milestone in our efforts to provide treatment with CD5 ATAK cells for patients with relapsed or refractory PTCL. 

“Currently, we are continuing through the dose-escalation cohorts of IMAGINE, which is designed to assess the safety and tolerability, optimal dose regimen, tumour penetration and preliminary efficacy of MT-101 in patients with PTCL. 

“Following conclusion of Phase I, we expect to expand quickly into the Phase II portion of this study, which we designed to support registration of MT-101.”

The company’s mRNA-engineered monocyte, MT-101, was advanced from conception and preclinical proof of concept to its first dose in humans in 18 months. 

The ATAK platform has been designed to promote broad anti-tumour activity and harness the innate abilities of myeloid cells.