Biotechnology firm Allegro Ophthalmics has reported positive top-line results from the DEL MAR Phase IIb stage 2 clinical trial of luminate as a sequential therapy to treat diabetic macular edema (DME) patients.

Luminate is an integrin peptide therapy being developed to target integrin receptors and inhibit blood vessel construction.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

The trial has met the primary endpoint with non-inferior visual acuity gains by using 1mg of luminate equivalent to 1.25mg bevacizumab monotherapy at all time periods.

Luminate additionally demonstrated 12-week durability following completion of three loading doses.

During the double masked, placebo-controlled, randomised, multi-centre trial, 0.5mg and 1.0mg of luminate was evaluated as a sequential therapy and as a combination therapy with anti-VEGF in 80 subjects over five months at 14 US sites.

"Positive results in DEL MAR stages 1 and 2 continue to confirm Luminate’s safety and efficacy, and its 12-week durability in patients with DME."

Allegro Ophthalmics president and chief medical officer Vicken Karageozian said: “Positive results in DEL MAR stages 1 and 2 continue to confirm Luminate’s safety and efficacy, and its 12-week durability in patients with DME.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“What’s more, about 60% of those treated in the DEL MAR trial had been chronic anti-VEGF users, which suggests that Luminate, with its unique mechanism of action, may successfully treat more patients, including those who don’t respond to anti-VEGF.”

The results during the trial are reported to have been achieved after one treatment with 1.25mg of bevacizumab, followed by three 1mg luminate injections with 12 weeks of treatment.

The findings were compared to those obtained after administration of five injections every four weeks with bevacizumab.

Furthermore, the vaccine was found to be well-tolerated without drug toxicity or intraocular inflammation, and its safety profile was consistent with previous trial findings.