French biopharmaceutical firm Erytech Pharma has reported positive results from the Phase IIb clinical trial of eryaspase (GRASPA) in combination with chemotherapy to treat patients with second-line metastatic pancreatic cancer.

Eryaspase is made up of an enzyme called L-asparaginase, encapsulated inside donor-derived red blood cells.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The trial's results showed that eryaspase met its co-primary endpoints, as well as demonstrated improvement in progression-free survival (PFS) and overall survival (OS).

The multi-centre, randomised Phase IIb trial assessed the product and chemotherapy combination in 140 subjects in France.

Erytech chairman and chief executive officer Gil Beyen said: "We have been studying the metabolic pathways for the past decade with the aim to develop effective treatments for patients with metabolically driven tumors. We are very excited by this new positive data.

"This provides further important clinical proof of concept supporting the development of eryaspase as a potential treatment in one of the most aggressive tumour types."

"They provide further important clinical proof of concept supporting the development of eryaspase as a potential treatment in one of the most aggressive tumour types.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

"We will now explore the path forward with clinicians and regulators to bring eryaspase to patients with metastatic pancreatic cancer as soon as possible."

The primary objective of the trial was to examine the effect of eryaspase on PFS or OS in patients with low ASNS.

Eryaspase in combination with chemotherapy is being further studied in a Phase I clinical trial in the US for treatment of adults with newly diagnosed acute lymphoblastic leukemia (ALL) and a Phase IIb trial in Europe in elderly patients with newly diagnosed acute myeloid leukemia (AML).

Image: Axial CT image showing macrocystic adenocarcinoma of the pancreatic head. Photo: courtesy of Mbq/German Wikipedia.