The study assessed OR502’s safety, tolerability, and preliminary anti-tumour activity in patients with advanced solid tumours. Credit: Indypendenz/Shutterstock.

OncoResponse has unveiled the outcomes from the Phase I trial of OR502, a humanised anti-leukocyte immunoglobulin like receptor B2 (LILRB2) antibody, for treating advanced solid tumours.

The multicentre, two-part, open-label, first-in-human study assessed OR502’s safety, tolerability, and preliminary anti-tumour activity both as a standalone therapy and in conjunction with cemiplimab, an anti-programmed cell death protein (PD)-1, in patients with advanced solid tumours.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The Part A dose-escalation phase of the trial was designed to identify the maximum-tolerated dose (MTD) or optimal dose for further evaluation.

Part B, the expansion phase, treated subjects with advanced solid tumours at two separate doses of OR502 to establish the recommended Phase II dose (RP2D) and to evaluate preliminary anti-tumour activity.

According to the findings, OR502 showed a safety profile, without any dose-limiting toxicity (DLT) or adverse events reported even at the maximum dose level.

The treatment exhibited ‘promising’ early efficacy signals as a monotherapy, including two partial responses (PR) and nine cases of stable disease (SD) out of 17 subjects, with a 65% disease control rate.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The company plans to advance OR502 into further trials, evaluating the antibody in two mini-cohorts of patients with cutaneous melanoma and non-small cell lung cancer (NSCLC).

OncoResponse chief scientific officer Kamal Puri said: “OR502 binds to LILRB2 in a unique way to reverse immunosuppression in cancer and offers a potential treatment option to patients who have otherwise struggled with CPI therapy effectiveness.

“OncoResponse has spent years devising strategies to block or reprogramme tumour-associated macrophages to drive anti-tumour activity. We are excited by the vast promise of OR502 with preclinical and initial clinical data showing superiority over other anti-LILRB2 antibodies.”

In September 2022, the company entered into a clinical supply agreement with Regeneron for Libtayo (cemiplimab) a PD-1 inhibitor.