The trial of Silmitasertib in adult Covid-19 patients is progressing at National Cheng Kung University Hospital in Taiwan. Credit: Corona Borealis Studio / Shutterstock.com.

Senhwa Biosciences has dosed the first subject in a Phase II clinical trial of its investigational drug, Silmitasertib (CX-4945), in adult Covid-19 patients admitted to the hospital. 

The trial is progressing in National Cheng Kung University Hospital in Taiwan. 

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

In April this year, the Taiwan Food and Drug Administration (FDA) granted approval for the Investigational New Drug (IND) application for launching the Phase II trial of Silmitasertib. 

Through this Phase II proof of concept trial, the company plans to validate Silmitasertib as a treatment approach effective for various immune diseases.

Silmitasertib acts on host cell CK2 protein and could be effective against the variants of the SARS-CoV-2 virus, as well as others, including influenza and respiratory syncytial virus (RSV). 

It was earlier analysed in two investigator-initiated trials (IIT) in the US. 

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Study data showed that Silmitasertib offered clinical benefits by expediting recovery speed in mildly, moderately or severely symptomatic Covid-19 patients. 

Apart from the Covid-19 trial, the company plans to analyse this therapy for other indications. 

Last month, Senhwa filed an IND application with the US to analyse Silmitasertib to treat viral infection-caused community-acquired pneumonia (CAP) in a Phase II trial. 

This randomised, controlled, interventional, multicentre trial is designed to analyse if early intervention with the drug could hinder CAP progression.

Increased release of cytokines is linked to infections caused by SARS-CoV-2 and influenza viruses.