Oramed to reinitiate pivotal type 2 diabetes trial after Phase III flop
Following a review of the trial data, Oramed discovered that the oral insulin candidate was effective in a particular subset of patients.
21 February 2024
21 February 2024
Following a review of the trial data, Oramed discovered that the oral insulin candidate was effective in a particular subset of patients.
Teva Pharmaceuticals and Sanofi signed a $1.5bn deal to co-develop the anti-TL1A therapy for inflammatory bowel disease in November 2023.
Polpharma’s biosimilar candidate PB106 showed non-inferiority to the reference therapy, Takeda’s Entyvo, in a Phase III trial.
The trial will assess the safety, immunogenicity, efficacy, and biomarker-based selection of NPX887 for various solid tumours.
The investigator-initiated, randomised, double-blind, placebo-controlled trial is anticipated to begin in mid-2024.
Roche will carry out and sponsor the randomised, international Phase Ib/II trial, which is part of its Morpheus-Liver programme.
The decision follows a serious adverse event of liver failure in a patient participating in the atopic dermatitis trial.
Tharimmune is planning to advance TH104 into a Phase II clinical trial later this year, funded by an $11m public offering from 2023.
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