Drug sales for major depressive disorders (MDD) in the US are expected to grow at a compound annual growth rate (CAGR) of 6.6% to reach $4.6bn by 2025, compared to $2.4bn in 2015, according to a report by GlobalData.

Titled 'PharmaPoint: Major Depressive Disorder – Global Drug Forecast and Market Assessment to 2025', the report states attributes the growth to the availability of a wide range of treatments and the commercial success of atypical antipsychotics.

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The same factors will help the country to remain the biggest major market for MDD drugs, adds the report.

Antipsychotics accounted for 39% of the MDD drug sales in the US in 2015 and their sales are expected to grow at a CAGR of 7.1% to reach $1.9bn in sales by the end of the forecast period, retaining their market share.

"The pipeline drugs are forecast to generate combined sales of more than $800m, led by Janssen’s esketamine, by 2025."

Drugs in the class are currently priced high, resulting in increasing sales of generic aripiprazole.

Abilify was the most-sold atypical antipsychotic in 2015 and its sales are expected to remain flat during the forecast period, due to competition from generics and Otsuka / Lundbeck’s Rexulti.

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The report further mentions five MDD drugs that are currently in late-stage pipeline and will enter the US market, which include Alkermes’ ALKS-5461, Allergan / Gedeon Richter / Mitsubishi Tanabe’s Vraylar, Axsome Therapeutics’ AXS-05, Janssen’s esketamine, and Allergan’s rapastinel.

The pipeline drugs are forecast to generate combined sales of more than $800m, led by Janssen’s esketamine, by 2025.