copd

Clinical stage biotechnology company Pulmatrix has started Phase IB clinical study of a bronchodilator therapy, PUR0200, for chronic obstructive pulmonary disease (COPD).

PUR0200 is a small molecule product that leverages the company’s novel inhaled dry powder delivery platform iSPERSE technology, which facilitates flow-rate independent high-efficiency drug delivery to the lungs.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Pulmatrix chief scientific officer Dr David Hava said PUR0200 has demonstrated good performance in preclinical evaluation models of airway bronchoconstriction.

"The engineered aerosol performance and delivery characteristics of the iSPERSE platform are expected to result in PUR0200 efficacy at low doses," Hava said.

"The engineered aerosol performance and delivery characteristics of the iSPERSE platform are expected to result in PUR0200 efficacy at low doses."

GOLD Stage 2/3 COPD patients will be enrolled in the trial, which is designed to assess the safety tolerability and the pharmacokinetic/pharmacodynamic profile besides PUR0200 dose response.

The five-way placebo controlled crossover study is being conducted by Quotient Clinical in Nottingham England in conjunction with the Medicines Evaluation Unit in Manchester England.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Quotient Clinical will use the flexible translational pharmaceutics platform to manufacture and supply the drug product.

Pulmatrix chief executive officer Dr Robert Clarke said: "We are hopeful that PUR0200 will be the first step in the establishment of a new generation of easily inhaled easy-to-use therapeutics based on the iSPERSE technology to serve COPD asthma Cystic Fibrosis and other patients suffering from respiratory disease."

The company expects to present the results in 2014.

Image: A chest X-ray demonstrating severe COPD. Note the small size of the heart in comparison to the lungs. Photo: courtesy of James Heilman.