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Bioavailability studies are performed to determine the movement of an active ingredient through the system into the systemic circulation and its action on the target site with minimum undesired off-target side effects.

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Bioavailability and bioequivalence studies are useful for studying new drugs for administration and help in establishing an equivalence between early and late clinical trial formulations and establishing an equivalence between formulations used in clinical trials and stability studies.

Bioequivalence studies help to ensure therapeutic equivalence between a pharmaceutically equivalent test drug and a generic or reference drug.

Studies such as bioanalysis help in the drug development process and pharmacokinetics studies, while biomarker testing is performed in disease monitoring, prevention, detection and determination of individual disease risk.

Discover the top suppliers of bioavailability research studies

Clinical Trials Arena has listed the leading bioavailability studies companies in clinical research based on its intel, insights, and decades-long experience in the sector. The list includes companies that provide various products and services, including but not limited to:

· Absolute bioavailability testing, comparative bioavailability studies, and bioequivalence testing

· Bioavailability testing assays and bioanalytical assays

· Method validation chemistry

· Microarray and clinical trial data analysis

· Assessment, product development and marketing of biomarkers

· Clinical image management

· Secure storage of clinical samples and biological materials

· Cold chain qualification tests

· Comparator drugs, ancillary supplies, and placebos

· Hydro gel-based tools for drug discovery and bioresearch applications

· Physiologically based pharmacokinetic (PBPK) and quantitative systems pharmacology (QSP) modelling and simulation

· Analysis of the glycosylation patterns of therapeutic proteins and monoclonal antibodies

· Exploratory drug development and ethnobridging studies

· Marine glycobiology

· Immunogenicity testing

The information contained within the download document is intended for pharmaceutical executives, manufacturers, distributors, suppliers, technicians, research scientists, product development scientists, and any other individual involved in clinical research and trials.

The document contains detailed information on the suppliers and their product offerings, as well as contact details to aid your purchasing or hiring decision.

Related Buyer’s Guides which cover an extensive range of clinical trial solutions suppliers, equipment and technology, can also be found here.

Bioavailability study methodology

Bioavailability may be assessed in two complementary ways, chemical methods and biological methods.

Within healthcare, the bioavailability of a drug from its dosage forms depends on pharmaceutical factors, patient-related factors and administration route, which may vary according to several factors such as selection of subjects, design study, washout period, study design (single dose vs multiple doses), conditions to perform the studies, and pharmacological effects produced by the drug metabolites.

For full details (including contact details) on the leading companies within this space, download the free Buyer’s Guide below:

Frequently asked questions

  • What is bioavailability in clinical trials?

    Bioavailability measures how much of an active drug ingredient is absorbed into the bloodstream and reaches the target site, ensuring the desired therapeutic effect. This is critical for drug efficacy and is often compared to bioequivalence, which assesses the similarity between two formulations.

  • Why are bioavailability studies important?

    Bioavailability studies ensure that drugs are absorbed efficiently and deliver consistent therapeutic effects. They are crucial in comparing different formulations, particularly for generics, ensuring that patients receive the same benefit from each version.

  • What are the key services offered by bioavailability study companies?

    Companies offering bioavailability studies provide services such as bioanalytical testing, method validation, and pharmacokinetics analysis. These services assess drug absorption rates, study formulation differences, and help in regulatory submissions.

  • How do bioequivalence studies support generic drug development?

    Bioequivalence studies demonstrate that a generic drug performs similarly to a brand-name drug in terms of absorption and effectiveness. This data is essential for regulatory approval, ensuring that generic medications are safe and effective alternatives.

  • What factors influence bioavailability in clinical trials?

    Factors like formulation, patient characteristics, route of administration, and the metabolic rate can influence a drug's bioavailability. Proper study design, including dosing, sampling methods, and participant selection, is critical for accurate results.