The ASPEN trial includes patients within the age group of 12 to 85 years. Credit: National Cancer Institute on Unsplash.

Insmed has completed the enrolment of over 1,700 adult patients for its ASPEN study of brensocatib to treat bronchiectasis.

Brensocatib has already secured breakthrough therapy designation from the US Food and Drug Administration (FDA) and the European Medicines Agency’s priority medicines (PRIME) designation, for use in bronchiectasis patients.    

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

ASPEN is a global, randomised, double-blind, placebo-controlled Phase III trial.

It has been designed to study brensocatib’s efficacy, safety and tolerability to treat patients with non-cystic fibrosis bronchiectasis.

The trial includes patients within the age group of 12 to 85 years.

In the trial, the adult patients have been randomised into 1:1:1 ratio to receive 10mg, 25mg doses of brensocatib or placebo.

The drug will be administered once daily for 52 weeks, with a follow-up period of four weeks after the treatment.

The trial’s primary endpoint is the rate of pulmonary exacerbations during the treatment period of 52 weeks.

Insmed plans to provide topline data from adults in the trial by the second quarter of next year.

The firm is currently conducting the ASPEN study at over 460 sites in around 40 countries worldwide. The process of enrolling adolescent patients aged 12 to less than 18 years for the study is now going on.

Insmed chief medical officer Martina Flammer said: “ASPEN is the largest single Phase III study ever conducted in bronchiectasis, a serious pulmonary disease that today has no approved treatments.

“We believe the pace of enrolment and enthusiasm of the treating community reflect the significant need for a therapy specifically developed for this disease.”